Skip to content
← Back to hotels in St. Louis, MO

3-star hotel · IHG HOTELS & RESORTS

Holiday Inn Express and Suites St.Louis South-I-55

St. Louis, MO, United States
Holiday Inn Express and Suites St.Louis South-I-55
Holiday Inn Express and Suites St.Louis South-I-55, property photo 1
1 / 24

A base in St. Louis, MO.

Welcome to the new Holiday Inn Express & Suites St. Louis South I-55! South St. Louis's newest and most modern Holiday Inn Express hotel is nestled within a growing development at the intersection of Butler Hill Road and I-55, just one mile south of I-270/255, with access to everything St. Louis offers. Located just 14 miles south of downtown St. Louis at exit 195 off I-55, business travelers will benefit from our central location with easy on/off access to I-55, connecting to different areas of St. Louis within minutes. The hotel complex includes the Barnes-Jewish Siteman Cancer Center and Mercy Health. We are also minutes from MetLife, Anheuser-Busch, Cigna, and the National Cemetery Administration. Our non-smoking Holiday Inn Express & Suites St. Louis I-55 hotel offers convenient access for guests visiting Busch Stadium, the Gateway Arch, Grant's Farm, the Magic House, the St. Louis Science Center, the St. Louis Zoo, Forest Park, River City Casino, and much more! Hotel guests can enjoy an array of amenities, including suites, an indoor pool, a Suite Shop, two meeting rooms, a complimentary Express Start breakfast, complimentary high-speed wired and wireless internet, a comfortable Great Room with an outdoor patio, and warm cookies and milk served nightly. Experience genuine Midwestern hospitality at our South St. Louis location.

  • Wi-fi
  • 24-hour reception
  • Indoor freshwater pool
  • Car park · extra charge
  • Fitness · extra charge
  • Launderette · extra charge

Explore room options

Room details are a guide. Nowah checks the exact room and guest combination for your dates.

Suite one bedroom accessible

Up to 8 guests

Confirm the exact bed arrangement and any child requirements with Nowah.

Explore room options with Nowah
Double king size bed

Up to 4 guests

1 × King-size bed 150-183 width

Wheelchair-accessible · Wi-fi

Confirm the exact bed arrangement and any child requirements with Nowah.

Explore room options with Nowah
Double deluxe king bed

Up to 4 guests

Confirm the exact bed arrangement and any child requirements with Nowah.

Explore room options with Nowah
Room standard

Up to 10 guests

Confirm the exact bed arrangement and any child requirements with Nowah.

Explore room options with Nowah
Double two queen beds

Up to 4 guests

2 × Queen-size bed 150-154 width

Wi-fi · Wheelchair-accessible

Confirm the exact bed arrangement and any child requirements with Nowah.

Explore room options with Nowah
Quadruple two queen beds non smoking

Up to 6 guests

Confirm the exact bed arrangement and any child requirements with Nowah.

Explore room options with Nowah
Suite two queen beds one bedroom

Up to 6 guests

2 × Queen-size bed 150-154 width

Wi-fi · Wheelchair-accessible

Confirm the exact bed arrangement and any child requirements with Nowah.

Explore room options with Nowah
Suite accessible king size bed

Up to 4 guests

1 × King-size bed 150-183 width

Wi-fi · Wheelchair-accessible

Confirm the exact bed arrangement and any child requirements with Nowah.

Explore room options with Nowah

Amenities & useful details

Facilities

  • Wi-fi
  • 24-hour reception
  • Car parkExtra charge
  • LaunderetteExtra charge
  • Laundry serviceExtra charge
  • Wheelchair-accessible
  • Babysitting serviceExtra charge
  • Bellboy serviceExtra charge
  • Lift accessExtra charge
  • ShopExtra charge

Entertainment

  • Indoor freshwater pool
  • CasinoExtra charge

Sports

  • FitnessExtra charge
  • GolfExtra charge
  • TennisExtra charge

Catering

  • BarExtra charge
  • Smoking areaExtra charge

Meals

  • Breakfast

Business

  • Business centreExtra charge
  • FaxExtra charge
  • Meeting room
  • PrinterExtra charge

Room facilities apply to the room type selected. Confirm any essential accessibility, service or equipment requirements before booking.

Find your bearings

4250 Midamerica Lane, 63129
St. Louis, MO, United States

Holiday Inn Express and Suites St.Louis South-I-55 · 4250 Midamerica Lane

Open location in OpenStreetMap ↗

Before you confirm

Cancellation terms, meals and room eligibility are checked with the selected offer in Nowah.

Ask Nowah about this hotel

Also explore in St. Louis, MO

Fairfield Inn & Suites by Marriott St. Louis South

St. Louis, MO, United States

Fairfield Inn & Suites by Marriott St. Louis South

Hotel · MARRIOTT HOTELS AND RESORTS

Enjoy a complimentary full breakfast on weekdays (6:30 AM - 9:30 AM) at the Fairfield Inn & Suites by Marriott St. Louis South. Stay connected with complimentary Wi-Fi and relax in one of the 77 guestrooms featuring flat-screen…

  • Wi-fi
  • 24-hour reception
  • Indoor freshwater pool
  • Car park
Americas Best Value Inn St. Louis South

St. Louis, MO, United States

Americas Best Value Inn St. Louis South

3-star hotel · SONESTA INTERNATIONAL HOTELS CORPORATION

A total of 95 accomodation units are available for guests' convenience. America's Best Value Inn St. Louis South offers Wi-Fi internet connection in communal areas. America's Best Value Inn St. Louis South provides 24-hour…

  • Wi-fi
  • 24-hour reception
  • Outdoor freshwater pool
  • Fitness
Drury Inn & Suites Arnold - St. Louis

St. Louis, MO, United States

Drury Inn & Suites Arnold - St. Louis

3-star hotel · Drury Hotels

Located in Arnold, this upper-midscale hotel provides a convenient base for travellers, situated 18 miles from St Louis city centre and near the I-55 motorway. Guests can enjoy a complimentary hot breakfast each morning. The…

  • Wi-fi
  • 24-hour reception
  • Fitness · extra charge
  • Restaurant

Keep exploring St. Louis, MO

Before you go to United States

Your whole trip, connected

A stay is only the beginning.

Keep your hotel, arrival and wider trip in one conversation.

Find a stay with Nowah